› 2kbc

Solution NMR

Solution structure of human insulin-like peptide 5 (INSL5)

Released:
DOI: 10.2210/pdb2kbc/pdb
PDB entry 2kbc coloured by chain, ensemble of 20 models, front view.
PDB entry 2kbc coloured by chain, ensemble of 20 models, side view.
PDB entry 2kbc coloured by chain, ensemble of 20 models, top view.
Source organism: Escherichia coli BL21(DE3)
Primary publication:
Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework.
Haugaard-Jönsson LM, Hossain MA, Daly NL, Craik DJ, Wade JD, Rosengren KJ
Biochem J 419 619-27 (2009)
PMID: 19178384

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195284 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin-like peptide INSL5 B chain Chain: B
Molecule details ›
Chain: B
Length: 25 amino acids
Theoretical weight: 2.85 KDa
Source organism: Escherichia coli BL21(DE3)
Expression system: Not provided
UniProt:
  • Canonical: Q9Y5Q6 (Residues: 23-46; Coverage: 21%)
Gene names: INSL5, UNQ156/PRO182
Insulin-like peptide INSL5 A chain Chain: A
Molecule details ›
Chain: A
Length: 22 amino acids
Theoretical weight: 2.2 KDa
Source organism: Escherichia coli BL21(DE3)
Expression system: Not provided
UniProt:
  • Canonical: Q9Y5Q6 (Residues: 115-135; Coverage: 19%)
Gene names: INSL5, UNQ156/PRO182

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

4 review citations

Relaxin family peptides and their receptors.
Bathgate et al. (2013)
3 more

4 mentions without citation

Relaxin family peptides: structure-activity relationship studies.
Patil et al. (2017)
3 more