› 2kbi

Solution NMR

Solution NMR structure of the C-terminal EF-hand domain of human cardiac sodium channel NaV1.5

Released:
DOI: 10.2210/pdb2kbi/pdb
PDB entry 2kbi coloured by chain, ensemble of 20 models, front view.
PDB entry 2kbi coloured by chain, ensemble of 20 models, side view.
PDB entry 2kbi coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution NMR structure of the C-terminal EF-hand domain of human cardiac sodium channel NaV1.5.
Chagot B, Potet F, Balser JR, Chazin WJ
J Biol Chem 284 6436-45 (2009)
PMID: 19074138

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172023 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium channel protein type 5 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 97 amino acids
Theoretical weight: 10.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14524 (Residues: 1773-1865; Coverage: 5%)
Gene name: SCN5A
Structure domains: EF-hand

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

19 review citations

Cardiac sodium channel Na(v)1.5 and interacting proteins: Physiology and pathophysiology.
Abriel H. (2010)
18 more

13 mentions without citation

Seeing the forest through the trees: towards a unified view on physiological calcium regulation of voltage-gated sodium channels.
Van Petegem et al. (2012)
12 more