Function and Biology Details
Biochemical function:
- not assigned
Biological process:
Cellular component:
Sequence domains:
- Bcl-2 family
- Apoptosis regulator, Mcl-1
- Bcl-2-like superfamily
- BH3-interacting domain death agonist
- Apoptosis regulator, Bcl-2, BH3 motif, conserved site
- Apoptosis regulator, Bcl-2, BH2 motif, conserved site
- Apoptosis regulator, Bcl-2, BH1 motif, conserved site
- Bcl-2, Bcl-2 homology region 1-3
1 more domain
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157366 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Induced myeloid leukemia cell differentiation protein Mcl-1
Molecule details ›
Chain: A
Length: 164 amino acids
Theoretical weight: 18.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like
Length: 164 amino acids
Theoretical weight: 18.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q07820 (Residues: 163-326; Coverage: 47%)
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like
BH3-interacting domain death agonist p11
Molecule details ›
Chain: B
Length: 35 amino acids
Theoretical weight: 3.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Length: 35 amino acids
Theoretical weight: 3.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P55957 (Residues: 76-106; Coverage: 16%)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Refinement method:
simulated annealing
Expression system: Escherichia coli
