› 2kcj

Solution NMR

solution structure of FAPP1 PH domain

Released:
DOI: 10.2210/pdb2kcj/pdb
PDB entry 2kcj coloured by chain, ensemble of 20 models, front view.
PDB entry 2kcj coloured by chain, ensemble of 20 models, side view.
PDB entry 2kcj coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of wedging the Golgi membrane by FAPP pleckstrin homology domains.
Lenoir M, Coskun U, Grzybek M, Cao X, Buschhorn SB, James J, Simons K, Overduin M
EMBO Rep 11 279-84 (2010)
PMID: 20300118

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190732 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pleckstrin homology domain-containing family A member 3 Chain: A
Molecule details ›
Chain: A
Length: 108 amino acids
Theoretical weight: 12.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9HB20 (Residues: 1-100; Coverage: 33%)
Gene names: FAPP1, PLEKHA3
Sequence domains: PH domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics, simulated annealing
Expression system: Escherichia coli

Quick links

Citations

29 review citations

Phosphoinositides: tiny lipids with giant impact on cell regulation.
Balla T. (2013)
28 more

4 mentions without citation

Conditional peripheral membrane proteins: facing up to limited specificity.
Moravcevic et al. (2012)
3 more