› 2kdd

Solution NMR

Solution structure of the conserved C-terminal dimerization domain of Borealin

Released:
DOI: 10.2210/pdb2kdd/pdb
PDB entry 2kdd coloured by chain, ensemble of 10 models, front view.
PDB entry 2kdd coloured by chain, ensemble of 10 models, side view.
PDB entry 2kdd coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation.
Bourhis E, Lingel A, Phung Q, Fairbrother WJ, Cochran AG
Biochemistry 48 6783-93 (2009)
PMID: 19530738

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176103 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Borealin Chains: A, B
Molecule details ›
Chains: A, B
Length: 76 amino acids
Theoretical weight: 8.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q53HL2 (Residues: 207-280; Coverage: 26%)
Gene names: CDCA8, PESCRG3
Sequence domains: Cell division cycle-associated protein 8
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 41%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Sensing centromere tension: Aurora B and the regulation of kinetochore function.
Lampson et al. (2011)
1 more

4 mentions without citation

Borealin-nucleosome interaction secures chromosome association of the chromosomal passenger complex.
Abad et al. (2019)
3 more