› 2ke5

Solution NMR

Solution structure and dynamics of the small GTPase Ralb in its active conformation: significance for effector protein binding

Released:
DOI: 10.2210/pdb2ke5/pdb
PDB entry 2ke5 coloured by chain, ensemble of 50 models, front view.
PDB entry 2ke5 coloured by chain, ensemble of 50 models, side view.
PDB entry 2ke5 coloured by chain, ensemble of 50 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding.
Fenwick RB, Prasannan S, Campbell LJ, Nietlispach D, Evetts KA, Camonis J, Mott HR, Owen D
Biochemistry 48 2192-206 (2009)
PMID: 19166349

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145723 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-related protein Ral-B Chain: A
Molecule details ›
Chain: A
Length: 174 amino acids
Theoretical weight: 19.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11234 (Residues: 12-185; Coverage: 85%)
Gene name: RALB
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand GNP 1 x GNP
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Structures of Ras superfamily effector complexes: What have we learnt in two decades?
Mott et al. (2015)
4 more

2 mentions without citation

Discovery and characterization of small molecules that target the GTPase Ral.
Yan et al. (2014)
1 more