› 2keb

Solution NMR

NMR solution structure of the N-terminal domain of the DNA polymerase alpha p68 subunit

Released:
DOI: 10.2210/pdb2keb/pdb
PDB entry 2keb coloured by chain, ensemble of 20 models, front view.
PDB entry 2keb coloured by chain, ensemble of 20 models, side view.
PDB entry 2keb coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of a DNA polymerase alpha-primase domain that docks on the SV40 helicase and activates the viral primosome.
Huang H, Weiner BE, Zhang H, Fuller BE, Gao Y, Wile BM, Zhao K, Arnett DR, Chazin WJ, Fanning E
J Biol Chem 285 17112-22 (2010)
PMID: 20234039

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171952 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA polymerase alpha subunit B Chain: A
Molecule details ›
Chain: A
Length: 101 amino acids
Theoretical weight: 11.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14181 (Residues: 1-78; Coverage: 13%)
Gene name: POLA2
Structure domains: DNA polymerase alpha-primase, subunit B, N-terminal domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Large T antigens of polyomaviruses: amazing molecular machines.
An et al. (2012)
2 more

5 mentions without citation

Structural basis for the interaction of a hexameric replicative helicase with the regulatory subunit of human DNA polymerase α-primase.
Zhou et al. (2012)
4 more