› 2kfh

Solution NMR

Structure of the C-terminal domain of EHD1 with FNYESTGPFTAK

Released:
DOI: 10.2210/pdb2kfh/pdb
PDB entry 2kfh coloured by chain, ensemble of 10 models, front view.
PDB entry 2kfh coloured by chain, ensemble of 10 models, side view.
PDB entry 2kfh coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural insight into the interaction of proteins containing NPF, DPF, and GPF motifs with the C-terminal EH-domain of EHD1.
Kieken F, Jović M, Tonelli M, Naslavsky N, Caplan S, Sorgen PL
Protein Sci 18 2471-9 (2009)
PMID: 19798736

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162816 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
EH domain-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 11.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H4M9 (Residues: 435-534; Coverage: 19%)
Gene names: CDABP0131, EHD1, PAST, PAST1
Sequence domains: Cytoskeletal-regulatory complex EF hand
Structure domains: EF-hand
Rab11-FIP2 GPF peptide FNYESTGPFTAK Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.36 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 86%
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

2 review citations

EHD proteins: key conductors of endocytic transport.
Naslavsky et al. (2011)
1 more

2 mentions without citation

Structural insight into the interaction of proteins containing NPF, DPF, and GPF motifs with the C-terminal EH-domain of EHD1.
Kieken et al. (2009)
1 more