› 2kg4

Solution NMR

Three-dimensional structure of human Gadd45alpha in solution by NMR

Released:
DOI: 10.2210/pdb2kg4/pdb
PDB entry 2kg4 coloured by chain, ensemble of 20 models, front view.
PDB entry 2kg4 coloured by chain, ensemble of 20 models, side view.
PDB entry 2kg4 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase.
Sánchez R, Pantoja-Uceda D, Prieto J, Diercks T, Marcaida MJ, Montoya G, Campos-Olivas R, Blanco FJ
J Biol Chem 285 22196-201 (2010)
PMID: 20460379

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Growth arrest and DNA damage-inducible protein GADD45 alpha Chain: A
Molecule details ›
Chain: A
Length: 165 amino acids
Theoretical weight: 18.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P24522 (Residues: 1-165; Coverage: 100%)
Gene names: DDIT1, GADD45, GADD45A
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Structure domains: 60s Ribosomal Protein L30; Chain: A;

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 83%
Refinement method: molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Aurora-A: a potential DNA repair modulator.
Wang et al. (2014)
1 more

1 mention without citation

Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase.
Sánchez et al. (2010)