› 2kht

Solid-state NMR

NMR Structure of human alpha defensin HNP-1

Released:
DOI: 10.2210/pdb2kht/pdb
PDB entry 2kht coloured by chain, ensemble of 10 models, front view.
PDB entry 2kht coloured by chain, ensemble of 10 models, side view.
PDB entry 2kht coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Resonance assignment and three-dimensional structure determination of a human alpha-defensin, HNP-1, by solid-state NMR.
Zhang Y, Doherty T, Li J, Lu W, Barinka C, Lubkowski J, Hong M
J Mol Biol 397 408-22 (2010)
PMID: 20097206

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157836 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neutrophil defensin 1 Chain: A
Molecule details ›
Chain: A
Length: 30 amino acids
Theoretical weight: 3.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P59665 (Residues: 65-94; Coverage: 40%)
Gene names: DEF1, DEFA1, DEFA1B, DEFA2, MRS
Sequence domains: Mammalian defensin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 37%
Refinement method: DGSA-distance geometry simulated annealing, simulated annealing
Expression system: Escherichia coli

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Citations

7 review citations

α-Defensins in human innate immunity.
Lehrer et al. (2012)
6 more

4 mentions without citation

ADP-ribosylation of arginine.
Laing et al. (2011)
3 more