› 2ki6

Solution NMR

The FGF1-S100A13-C2A hetero-hexameric complex structure: A component in the non-classical pathway for FGF1 secretion

Released:
DOI: 10.2210/pdb2ki6/pdb
PDB entry 2ki6 coloured by chain, ensemble of 18 models, front view.
PDB entry 2ki6 coloured by chain, ensemble of 18 models, side view.
PDB entry 2ki6 coloured by chain, ensemble of 18 models, top view.
Source organism: Homo sapiens
Primary publication:
The heterohexameric complex structure, a component in the non-classical pathway for fibroblast growth factor 1 (FGF1) secretion.
Mohan SK, Rani SG, Yu C
J Biol Chem 285 15464-15475 (2010)
PMID: 20220137

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-138610 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Synaptotagmin-1 Chains: A, F
Molecule details ›
Chains: A, F
Length: 128 amino acids
Theoretical weight: 14.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P21579 (Residues: 141-268; Coverage: 30%)
Gene names: SVP65, SYT, SYT1
Sequence domains: C2 domain
Structure domains: C2 domain
Fibroblast growth factor 1 Chains: B, E
Molecule details ›
Chains: B, E
Length: 133 amino acids
Theoretical weight: 15.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05230 (Residues: 23-155; Coverage: 86%)
Gene names: FGF1, FGFA
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Protein S100-A13 Chain: C
Molecule details ›
Chain: C
Length: 98 amino acids
Theoretical weight: 11.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99584 (Residues: 1-98; Coverage: 100%)
Gene name: S100A13
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand
Protein S100-A13 Chain: D
Molecule details ›
Chain: D
Length: 98 amino acids
Theoretical weight: 11.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99584 (Residues: 1-98; Coverage: 100%)
Gene name: S100A13
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

No bound ligands
1 modified residue:
Ligand DLY 3 x DLY

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles.
György et al. (2011)
5 more

2 mentions without citation

The heterohexameric complex structure, a component in the non-classical pathway for fibroblast growth factor 1 (FGF1) secretion.
Mohan et al. (2010)
1 more