› 2kiz

Solution NMR

Solution structure of Arkadia RING-H2 finger domain

Released:
DOI: 10.2210/pdb2kiz/pdb
PDB entry 2kiz coloured by chain, ensemble of 31 models, front view.
PDB entry 2kiz coloured by chain, ensemble of 31 models, side view.
PDB entry 2kiz coloured by chain, ensemble of 31 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR-based insights into the conformational and interaction properties of Arkadia RING-H2 E3 Ub ligase.
Chasapis CT, Kandias NG, Episkopou V, Bentrop D, Spyroulias GA
Proteins 80 1484-9 (2012)
PMID: 22411132

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180588 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase Arkadia Chain: A
Molecule details ›
Chain: A
Length: 69 amino acids
Theoretical weight: 7.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6ZNA4 (Residues: 927-994; Coverage: 7%)
Gene name: RNF111
Sequence domains: Ring finger domain

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Recent aspects of the effects of zinc on human health.
Chasapis et al. (2020)
4 more

7 mentions without citation

The MDM2 gene family.
Mendoza et al. (2014)
6 more