› 2kkj

Solution NMR

Solution structure of the Nuclear coactivator binding domain of CBP

Released:
DOI: 10.2210/pdb2kkj/pdb
PDB entry 2kkj coloured by chain, ensemble of 10 models, front view.
PDB entry 2kkj coloured by chain, ensemble of 10 models, side view.
PDB entry 2kkj coloured by chain, ensemble of 10 models, top view.
Source organism: Mus musculus
Primary publication:
Conformational selection in the molten globule state of the nuclear coactivator binding domain of CBP.
Kjaergaard M, Teilum K, Poulsen FM
Proc Natl Acad Sci U S A 107 12535-40 (2010)
PMID: 20616042

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155294 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone lysine acetyltransferase CREBBP Chain: A
Molecule details ›
Chain: A
Length: 59 amino acids
Theoretical weight: 6.57 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P45481 (Residues: 2059-2117; Coverage: 2%)
Gene names: Cbp, Crebbp
Sequence domains: Creb binding
Structure domains: Nuclear receptor coactivator, CREB-bp-like, interlocking domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

20 review citations

Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs).
Theillet et al. (2014)
19 more

19 mentions without citation

Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives.
Andreoli et al. (2013)
18 more