› 2klr

Solid-state NMR

Solid-state NMR structure of the alpha-crystallin domain in alphaB-crystallin oligomers

Released:
DOI: 10.2210/pdb2klr/pdb
PDB entry 2klr coloured by chain, ensemble of 10 models, front view.
PDB entry 2klr coloured by chain, ensemble of 10 models, side view.
PDB entry 2klr coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Solid-state NMR and SAXS studies provide a structural basis for the activation of alphaB-crystallin oligomers.
Jehle S, Rajagopal P, Bardiaux B, Markovic S, Kühne R, Stout JR, Higman VA, Klevit RE, van Rossum BJ, Oschkinat H
Nat Struct Mol Biol 17 1037-42 (2010)
PMID: 20802487

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135876 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-crystallin B chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 175 amino acids
Theoretical weight: 20.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02511 (Residues: 1-175; Coverage: 100%)
Gene names: CRYA2, CRYAB, HSPB5
Sequence domains:
Structure domains: Immunoglobulin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, molecular dynamics, torsion angle dynamics
Expression system: Escherichia coli

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Citations

27 review citations

Large potentials of small heat shock proteins.
Mymrikov et al. (2011)
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26 mentions without citation

A first line of stress defense: small heat shock proteins and their function in protein homeostasis.
Haslbeck et al. (2015)
25 more