› 2klu

Solution NMR

NMR structure of the transmembrane and cytoplasmic domains of human CD4

Released:
DOI: 10.2210/pdb2klu/pdb
PDB entry 2klu coloured by chain, ensemble of 20 models, front view.
PDB entry 2klu coloured by chain, ensemble of 20 models, side view.
PDB entry 2klu coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR structure of the transmembrane and cytoplasmic domains of human CD4 in micelles.
Wittlich M, Thiagarajan P, Koenig BW, Hartmann R, Willbold D
Biochim Biophys Acta 1798 122-7 (2010)
PMID: 19781520

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134521 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-cell surface glycoprotein CD4 Chain: A
Molecule details ›
Chain: A
Length: 70 amino acids
Theoretical weight: 7.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01730 (Residues: 397-458; Coverage: 14%)
Gene name: CD4
Sequence domains: T cell CD4 receptor C terminal region
Structure domains: transmembrane domain of human cd4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Understanding single-pass transmembrane receptor signaling from a structural viewpoint-what are we missing?
Bugge et al. (2016)
2 more

7 mentions without citation

Conformational Masking and Receptor-Dependent Unmasking of Highly Conserved Env Epitopes Recognized by Non-Neutralizing Antibodies That Mediate Potent ADCC against HIV-1.
Lewis et al. (2015)
6 more