› 2kn4

Solution NMR

The structure of the RRM domain of SC35

Released:
DOI: 10.2210/pdb2kn4/pdb
PDB entry 2kn4 coloured by chain, ensemble of 20 models, front view.
PDB entry 2kn4 coloured by chain, ensemble of 20 models, side view.
PDB entry 2kn4 coloured by chain, ensemble of 20 models, top view.
Source organisms:
Primary publication:
The structure and selectivity of the SR protein SRSF2 RRM domain with RNA.
Phelan MM, Goult BT, Clayton JC, Hautbergue GM, Wilson SA, Lian LY
Nucleic Acids Res 40 3232-44 (2012)
PMID: 22140111

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148787 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Immunoglobulin G-binding protein G; Serine/arginine-rich splicing factor 2 Chain: A
Molecule details ›
Chain: A
Length: 158 amino acids
Theoretical weight: 18.13 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P19909 (Residues: 304-360; Coverage: 10%)
  • Canonical: Q01130 (Residues: 9-101; Coverage: 42%)
Gene names: SFRS2, SRSF2, spg
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, molecular dynamics, torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy.
Hahn et al. (2015)
3 more

3 mentions without citation

SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML).
Meggendorfer et al. (2012)
2 more