› 2kn6

Solution NMR

Structure of full-length human ASC (Apoptosis-associated speck-like protein containing a CARD)

Released:
DOI: 10.2210/pdb2kn6/pdb
PDB entry 2kn6 coloured by chain, ensemble of 20 models, front view.
PDB entry 2kn6 coloured by chain, ensemble of 20 models, side view.
PDB entry 2kn6 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure and interdomain dynamics of apoptosis-associated speck-like protein containing a CARD (ASC).
de Alba E
J Biol Chem 284 32932-41 (2009)
PMID: 19759015

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193947 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apoptosis-associated speck-like protein containing a CARD Chain: A
Molecule details ›
Chain: A
Length: 215 amino acids
Theoretical weight: 23.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9ULZ3 (Residues: 1-195; Coverage: 100%)
Gene names: ASC, CARD5, PYCARD, TMS1
Sequence domains:
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Escherichia coli

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Citations

28 review citations

Regulation of inflammasome signaling.
Rathinam et al. (2012)
27 more

38 mentions without citation

Structural mechanisms in NLR inflammasome signaling.
Lechtenberg et al. (2014)
37 more