› 2kna

Solution NMR

Solution structure of UBA domain of XIAP

Released:
DOI: 10.2210/pdb2kna/pdb
PDB entry 2kna coloured by chain, ensemble of 15 models, front view.
PDB entry 2kna coloured by chain, ensemble of 15 models, side view.
PDB entry 2kna coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Backbone and side-chain 1H, 13C and 15N assignments of the ubiquitin-associated domain of human X-linked inhibitor of apoptosis protein.
Hui SK, Tse MK, Yang Y, Wong BC, Sze KH
Biomol NMR Assign 4 13-5 (2010)
PMID: 19916060

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161361 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase XIAP Chain: A
Molecule details ›
Chain: A
Length: 104 amino acids
Theoretical weight: 11.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P98170 (Residues: 357-449; Coverage: 19%)
Gene names: API3, BIRC4, IAP3, XIAP
Sequence domains: BIRC2/3-like, UBA domain
Structure domains: DNA helicase RuvA subunit, C-terminal domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics
Expression system: Escherichia coli

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Citations

1 citations in other articles

Structural analysis of the UBA domain of X-linked inhibitor of apoptosis protein reveals different surfaces for ubiquitin-binding and self-association.
Tse et al. (2011)

5 mentions without citation

Highly precise protein-protein interaction prediction based on consensus between template-based and de novo docking methods.
Ohue et al. (2013)
4 more