2knh

Solution NMR

The Solution structure of the eTAFH domain of AML1-ETO complexed with HEB peptide

Released:

Function and Biology Details

Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-170347 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein CBFA2T1 Chain: A
Molecule details ›
Chain: A
Length: 103 amino acids
Theoretical weight: 11.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06455 (Residues: 119-216; Coverage: 16%)
Gene names: AML1T1, CBFA2T1, CDR, ETO, MTG8, RUNX1T1, ZMYND2
Sequence domains: NHR1 homology to TAF
Structure domains: TAFH/NHR1 domain
Transcription factor 12 Chain: B
Molecule details ›
Chain: B
Length: 18 amino acids
Theoretical weight: 1.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99081 (Residues: 11-28; Coverage: 3%)
Gene names: BHLHB20, HEB, HTF4, TCF12

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 81%
Refinement method: simulated annealing
Expression system: Escherichia coli