› 2kol

Solution NMR

Solution structure of human SDF1-alpha H25R

Released:
DOI: 10.2210/pdb2kol/pdb
PDB entry 2kol coloured by chain, ensemble of 20 models, front view.
PDB entry 2kol coloured by chain, ensemble of 20 models, side view.
PDB entry 2kol coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Volkman BF, Ziarek JJ, Peterson FC, Veldkamp CT

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155703 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stromal cell-derived factor 1 Chain: A
Molecule details ›
Chain: A
Length: 68 amino acids
Theoretical weight: 8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48061 (Residues: 22-89; Coverage: 94%)
Gene names: CXCL12, SDF1, SDF1A, SDF1B
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 90%
Refinement method: AUTOMATED METHODS WERE USED FOR BACKBONE CHEMICAL SHIFT ASSIGNMENT AND ITERATIVE NOE REFINEMENT. FINAL STRUCTURES WERE OBTAINED BY MOLECULAR DYNAMICS IN EXPLICIT SOLVENT
Expression system: Escherichia coli

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