› 2ks9

Solution NMR

Solution conformation of substance P in water complexed with NK1R

Released:
DOI: 10.2210/pdb2ks9/pdb
PDB entry 2ks9 coloured by chain, ensemble of 5 models, front view.
PDB entry 2ks9 coloured by chain, ensemble of 5 models, side view.
PDB entry 2ks9 coloured by chain, ensemble of 5 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles.
Gayen A, Goswami SK, Mukhopadhyay C
Biochim Biophys Acta 1808 127-39 (2011)
PMID: 20937248

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148962 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Substance-P receptor Chain: A
Molecule details ›
Chain: A
Length: 364 amino acids
Theoretical weight: 41.68 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P25103 (Residues: 1-364; Coverage: 89%)
Gene names: NK1R, TAC1R, TACR1
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Structure domains: Rhodopsin 7-helix transmembrane proteins
Substance P Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.35 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P20366 (Residues: 58-68; Coverage: 10%)
Gene names: NKA, NKNA, TAC1, TAC2
Sequence domains: Tachykinin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics, simulated annealing
Expression system: Not provided

Quick links

Citations

1 review citation

The magic of bicelles lights up membrane protein structure.
Dürr et al. (2012)
15 other articles

20 mentions without citation

Neuropeptide substance P and the immune response.
Mashaghi et al. (2016)
19 more