› 2ktb

Solution NMR

Solution Structure of the Second Bromodomain of Human Polybromo in complex with an acetylated peptide from Histone 3

Released:
DOI: 10.2210/pdb2ktb/pdb
PDB entry 2ktb coloured by chain, ensemble of 20 models, front view.
PDB entry 2ktb coloured by chain, ensemble of 20 models, side view.
PDB entry 2ktb coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2.
Charlop-Powers Z, Zeng L, Zhang Q, Zhou MM
Cell Res 20 529-38 (2010)
PMID: 20368734

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162845 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
H3_Peptide Chain: A
Molecule details ›
Chain: A
Length: 20 amino acids
Theoretical weight: 2.23 KDa
Source organism: Homo sapiens
Expression system: Not provided
Protein polybromo-1 Chain: B
Molecule details ›
Chain: B
Length: 121 amino acids
Theoretical weight: 13.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86U86 (Residues: 174-293; Coverage: 7%)
Gene names: BAF180, PB1, PBRM1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

No bound ligands
1 modified residue:
Ligand ALY 1 x ALY

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, torsion angle dynamics
Expression systems:
  • Not provided
  • Escherichia coli

Quick links

Citations

15 review citations

Readers of histone modifications.
Yun et al. (2011)
14 more

3 mentions without citation

Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2.
Charlop-Powers et al. (2010)
2 more