› 2kv9

Solution NMR

Integrin beta3 subunit in a disulfide linked alphaIIb-beta3 cytosolic domain

Released:
DOI: 10.2210/pdb2kv9/pdb
PDB entry 2kv9 coloured by chain, ensemble of 20 models, front view.
PDB entry 2kv9 coloured by chain, ensemble of 20 models, side view.
PDB entry 2kv9 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR analysis of the alphaIIb beta3 cytoplasmic interaction suggests a mechanism for integrin regulation.
Metcalf DG, Moore DT, Wu Y, Kielec JM, Molnar K, Valentine KG, Wand AJ, Bennett JS, DeGrado WF
Proc Natl Acad Sci U S A 107 22481-6 (2010)
PMID: 21156831

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138433 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin beta-3 Chain: B
Molecule details ›
Chain: B
Length: 75 amino acids
Theoretical weight: 8.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P05106 (Residues: 739-788; Coverage: 7%)
Gene names: GP3A, ITGB3
Sequence domains: Integrin beta cytoplasmic domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 87%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

15 review citations

Integrin cytoplasmic tail interactions.
Morse et al. (2014)
14 more

4 mentions without citation

NMR analysis of the alphaIIb beta3 cytoplasmic interaction suggests a mechanism for integrin regulation.
Metcalf et al. (2010)
3 more