› 2kwf

Solution NMR

The structure of E-protein activation domain 1 bound to the KIX domain of CBP/p300 elucidates leukemia induction by E2A-PBX1

Released:
DOI: 10.2210/pdb2kwf/pdb
PDB entry 2kwf coloured by chain, ensemble of 20 models, front view.
PDB entry 2kwf coloured by chain, ensemble of 20 models, side view.
PDB entry 2kwf coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Denis CM, Chitayat S, Plevin MJ, Liu S, Spencer HL, Ikura M, LeBrun DP, Smith SP

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147516 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
CREB-binding protein Chain: A
Molecule details ›
Chain: A
Length: 87 amino acids
Theoretical weight: 10.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92793 (Residues: 587-673; Coverage: 4%)
Gene names: CBP, CREBBP
Sequence domains: KIX domain
Structure domains: Coactivator CBP, KIX domain
Transcription factor 4 Chain: B
Molecule details ›
Chain: B
Length: 19 amino acids
Theoretical weight: 2.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15884 (Residues: 11-27; Coverage: 3%)
Gene names: BHLHB19, ITF2, SEF2, TCF4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

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