› 2kxs

Solution NMR

ZO1 ZU5 domain in complex with GRINL1A peptide

Released:
DOI: 10.2210/pdb2kxs/pdb
PDB entry 2kxs coloured by chain, ensemble of 20 models, front view.
PDB entry 2kxs coloured by chain, ensemble of 20 models, side view.
PDB entry 2kxs coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration.
Huo L, Wen W, Wang R, Kam C, Xia J, Feng W, Zhang M
EMBO J 30 665-78 (2011)
PMID: 21240187

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143192 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myocardial zonula adherens protein; Tight junction protein ZO-1 Chain: A
Molecule details ›
Chain: A
Length: 146 amino acids
Theoretical weight: 15.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07157 (Residues: 1631-1748; Coverage: 7%)
  • Canonical: P0CAP1 (Residues: 70-79; Coverage: 2%)
Gene names: MYOZAP, MYZAP, TJP1, ZO1
Sequence domains: ZU5 domain
Structure domains: Chondroitinase Ac; Chain A, domain 3

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

10 review citations

AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases.
Arencibia et al. (2013)
9 more

3 mentions without citation

Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration.
Huo et al. (2011)
2 more