› 2kyk

Solution NMR

The sandwich region between two LMP2A PY motif regulates the interaction between AIP4WW2domain and PY motif

Released:
DOI: 10.2210/pdb2kyk/pdb
PDB entry 2kyk coloured by chain, ensemble of 20 models, front view.
PDB entry 2kyk coloured by chain, ensemble of 20 models, side view.
PDB entry 2kyk coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Seo M, Park S, Seok S, Kim J, Cha M, Lee B

Function and Biology Details

Reaction catalysed: 
(1a) S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [HECT-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + S-ubiquitinyl-[HECT-type E3 ubiquitin transferase]-L-cysteine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188555 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase Itchy homolog Chain: A
Molecule details ›
Chain: A
Length: 39 amino acids
Theoretical weight: 4.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96J02 (Residues: 359-392; Coverage: 4%)
Gene name: ITCH
Sequence domains: WW domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

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