› 2kyl

Solution NMR

Solution structure of MAST2-PDZ complexed with the C-terminus of PTEN

Released:
DOI: 10.2210/pdb2kyl/pdb
PDB entry 2kyl coloured by chain, ensemble of 10 models, front view.
PDB entry 2kyl coloured by chain, ensemble of 10 models, side view.
PDB entry 2kyl coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Entry authors: Terrien E, Wolff N, Cordier F, Simenel C, Lafon M, Delepierre M

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158018 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Microtubule-associated serine/threonine-protein kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 96 amino acids
Theoretical weight: 10.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6P0Q8 (Residues: 1099-1193; Coverage: 5%)
Gene names: KIAA0807, MAST2, MAST205
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Chain: B
Molecule details ›
Chain: B
Length: 13 amino acids
Theoretical weight: 1.56 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P60484 (Residues: 391-403; Coverage: 3%)
Gene names: MMAC1, PTEN, TEP1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 87%
Refinement method: torsion angle dynamics
Expression systems:
  • Escherichia coli
  • Not provided

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