› 2l23

Solution NMR

NMR structure of the ACID (ACtivator Interacting Domain) of the human mediator Med25 protein

Released:
DOI: 10.2210/pdb2l23/pdb
PDB entry 2l23 coloured by chain, ensemble of 20 models, front view.
PDB entry 2l23 coloured by chain, ensemble of 20 models, side view.
PDB entry 2l23 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR structure of the human Mediator MED25 ACID domain.
Bontems F, Verger A, Dewitte F, Lens Z, Baert JL, Ferreira E, de Launoit Y, Sizun C, Guittet E, Villeret V, Monté D
J Struct Biol 174 245-51 (2011)
PMID: 20974256

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180759 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mediator of RNA polymerase II transcription subunit 25 Chain: A
Molecule details ›
Chain: A
Length: 167 amino acids
Theoretical weight: 19.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q71SY5 (Residues: 391-548; Coverage: 21%)
Gene names: ACID1, ARC92, MED25, PTOV2, TCBAP0758
Sequence domains: Mediator complex subunit 25 PTOV activation and synapsin 2
Structure domains: Mediator complex subunit 25, ACID domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Origins and activity of the Mediator complex.
Conaway et al. (2011)
4 more

4 mentions without citation

Twenty years of Mediator complex structural studies.
Verger et al. (2019)
3 more