Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134263 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cation-independent mannose-6-phosphate receptor
Molecule details ›
Chain: A
Length: 142 amino acids
Theoretical weight: 15.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Cation-independent mannose-6-phosphate receptor repeat
Structure domains: Mannose-6-phosphate receptor binding domain
Length: 142 amino acids
Theoretical weight: 15.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P11717 (Residues: 1508-1647; Coverage: 6%)
Sequence domains: Cation-independent mannose-6-phosphate receptor repeat
Structure domains: Mannose-6-phosphate receptor binding domain
Insulin-like growth factor II
Molecule details ›
Chain: B
Length: 67 amino acids
Theoretical weight: 7.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Insulin/IGF/Relaxin family
Structure domains: Insulin-like
Length: 67 amino acids
Theoretical weight: 7.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P01344 (Residues: 25-91; Coverage: 43%)
Sequence domains: Insulin/IGF/Relaxin family
Structure domains: Insulin-like
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Chemical shift assignment:
84%
Refinement method:
simulated annealing, simulated annealing
Expression system: Escherichia coli
