› 2l4n

Solution NMR

Solution Structure of the Chemokine CCL21

Released:
DOI: 10.2210/pdb2l4n/pdb
PDB entry 2l4n coloured by chain, ensemble of 20 models, front view.
PDB entry 2l4n coloured by chain, ensemble of 20 models, side view.
PDB entry 2l4n coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of CCL21 and identification of a putative CCR7 binding site.
Love M, Sandberg JL, Ziarek JJ, Gerarden KP, Rode RR, Jensen DR, McCaslin DR, Peterson FC, Veldkamp CT
Biochemistry 51 733-5 (2012)
PMID: 22221265

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126361 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-C motif chemokine 21 Chain: A
Molecule details ›
Chain: A
Length: 113 amino acids
Theoretical weight: 12.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00585 (Residues: 24-134; Coverage: 100%)
Gene names: CCL21, SCYA21, UNQ784/PRO1600
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 84%
Refinement method: AUTOMATED METHODS WERE USED FOR BACKBONE CHEMICAL SHIFT ASSIGNMENT AND ITERATIVE NOE REFINEMENT. FINAL STRUCTURES WERE OBTAINED BY MOLECULAR DYNAMICS IN EXPLICIT SOLVENT
Expression system: Escherichia coli

Quick links

Citations

4 review citations

New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model.
Kleist et al. (2016)
3 more

12 mentions without citation

The marriage of chemokines and galectins as functional heterodimers.
von Hundelshausen et al. (2021)
11 more