› 2l7p

Solution NMR

ASHH2 a CW domain

Released:
DOI: 10.2210/pdb2l7p/pdb
PDB entry 2l7p coloured by chain, ensemble of 20 models, front view.
PDB entry 2l7p coloured by chain, ensemble of 20 models, side view.
PDB entry 2l7p coloured by chain, ensemble of 20 models, top view.
Source organism: Arabidopsis thaliana
Primary publication:
The CW domain, a new histone recognition module in chromatin proteins.
Hoppmann V, Thorstensen T, Kristiansen PE, Veiseth SV, Rahman MA, Finne K, Aalen RB, Aasland R
EMBO J 30 1939-52 (2011)
PMID: 21522130

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173701 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone-lysine N-methyltransferase ASHH2 Chain: A
Molecule details ›
Chain: A
Length: 100 amino acids
Theoretical weight: 11.21 KDa
Source organism: Arabidopsis thaliana
Expression system: Escherichia coli
UniProt:
  • Canonical: Q2LAE1 (Residues: 849-937; Coverage: 5%)
Gene names: ASHH2, At1g77300, EFS, LAZ2, SDG8, SET8, T14N5.15
Sequence domains: CW-type Zinc Finger

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 92%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

16 review citations

Histone methylation: a dynamic mark in health, disease and inheritance.
Greer et al. (2012)
15 more

4 mentions without citation

Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis.
Chen et al. (2021)
3 more