› 2l7s

Solution NMR

Determination of the three-dimensional structure of adrenomedullin, a first step towards the analysis of its interactions with receptors and small molecules

Released:
DOI: 10.2210/pdb2l7s/pdb
PDB entry 2l7s coloured by chain, ensemble of 20 models, front view.
PDB entry 2l7s coloured by chain, ensemble of 20 models, side view.
PDB entry 2l7s coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of micelle-bound adrenomedullin: a first step toward the analysis of its interactions with receptors and small molecules.
Pérez-Castells J, Martín-Santamaría S, Nieto L, Ramos A, Martínez A, Pascual-Teresa Bd, Jiménez-Barbero J
Biopolymers 97 45-53 (2012)
PMID: 21830197

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152886 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adrenomedullin Chain: A
Molecule details ›
Chain: A
Length: 53 amino acids
Theoretical weight: 6.04 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P35318 (Residues: 95-146; Coverage: 32%)
Gene names: ADM, AM
Sequence domains: Calcitonin / CGRP / IAPP family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 52%
Refinement method: simulated annealing, molecular dynamics
Expression system: Not provided

Quick links

Citations

7 review citations

Receptor Activity-Modifying Proteins (RAMPs): New Insights and Roles.
Hay et al. (2016)
6 more

3 mentions without citation

Structure-activity relationships for α-calcitonin gene-related peptide.
Watkins et al. (2013)
2 more