› 2l80

Solution NMR

Solution Structure of the Zinc Finger Domain of USP13

Released:
DOI: 10.2210/pdb2l80/pdb
PDB entry 2l80 coloured by chain, ensemble of 10 models, front view.
PDB entry 2l80 coloured by chain, ensemble of 10 models, side view.
PDB entry 2l80 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Entry authors: Zhang Y, Zhou C, Zhou Z, Song A, Hu H

Function and Biology Details

Reaction catalysed: 
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187829 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ubiquitin carboxyl-terminal hydrolase 13 Chain: A
Molecule details ›
Chain: A
Length: 116 amino acids
Theoretical weight: 12.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92995 (Residues: 188-301; Coverage: 13%)
Gene names: ISOT3, USP13
Sequence domains: Zn-finger in ubiquitin-hydrolases and other protein
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 80%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)

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