› 2l8s

Solution NMR

Solution NMR Structure of Transmembrane and Cytosolic Regions of Integrin Alpha1 in Detergent Micelles

Released:
DOI: 10.2210/pdb2l8s/pdb
PDB entry 2l8s coloured by chain, ensemble of 10 models, front view.
PDB entry 2l8s coloured by chain, ensemble of 10 models, side view.
PDB entry 2l8s coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Integrin α1 has a long helix, extending from the transmembrane region to the cytoplasmic tail in detergent micelles.
Lai C, Liu X, Tian C, Wu F
PLoS One 8 e62954 (2013)
PMID: 23646163

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157417 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 54 amino acids
Theoretical weight: 6.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P56199 (Residues: 1135-1179; Coverage: 4%)
Gene name: ITGA1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 63%
Refinement method: simulated annealing
Expression system: Escherichia coli

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Citations

1 review citation

Understanding single-pass transmembrane receptor signaling from a structural viewpoint-what are we missing?
Bugge et al. (2016)
5 other articles

6 mentions without citation

The role of junctophilin proteins in cellular function.
Lehnart et al. (2022)
5 more