› 2lck

Solution NMR

Structure of the mitochondrial uncoupling protein 2 determined by NMR molecular fragment replacement

Released:
DOI: 10.2210/pdb2lck/pdb
PDB entry 2lck coloured by chain, ensemble of 15 models, front view.
PDB entry 2lck coloured by chain, ensemble of 15 models, side view.
PDB entry 2lck coloured by chain, ensemble of 15 models, top view.
Source organism: Mus musculus
Primary publication:
Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching.
Berardi MJ, Shih WM, Harrison SC, Chou JJ
Nature 476 109-13 (2011)
PMID: 21785437

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159730 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dicarboxylate carrier SLC25A8 Chain: A
Molecule details ›
Chain: A
Length: 303 amino acids
Theoretical weight: 33.06 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P70406 (Residues: 14-309; Coverage: 96%)
Gene names: Slc25a8, Ucp2
Sequence domains: Mitochondrial carrier protein
Structure domains: Mitochondrial carrier domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 34%
Refinement method: RDC-based Molecular Fragment Replacement, simulated annealing
Expression system: Escherichia coli

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Citations

39 review citations

Challenges and opportunities for structural DNA nanotechnology.
Pinheiro et al. (2011)
38 more

25 mentions without citation

Physiological and pathological roles of mitochondrial SLC25 carriers.
Gutiérrez-Aguilar et al. (2013)
24 more