› 2ld0

Solution NMR

Solution structure of the N-terminal domain of huntingtin (htt17) in 50 % TFE

Released:
DOI: 10.2210/pdb2ld0/pdb
PDB entry 2ld0 coloured by chain, ensemble of 20 models, front view.
PDB entry 2ld0 coloured by chain, ensemble of 20 models, side view.
PDB entry 2ld0 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure and topology of the huntingtin 1-17 membrane anchor by a combined solution and solid-state NMR approach.
Michalek M, Salnikov ES, Bechinger B
Biophys J 105 699-710 (2013)
PMID: 23931318

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154897 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Huntingtin Chain: A
Molecule details ›
Chain: A
Length: 18 amino acids
Theoretical weight: 1.98 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P42858 (Residues: 1-17; Coverage: 1%)
Gene names: HD, HTT, IT15

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 34%
Refinement method: molecular dynamics
Expression system: Not provided

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Citations

6 review citations

Proteins Containing Expanded Polyglutamine Tracts and Neurodegenerative Disease.
Adegbuyiro et al. (2017)
5 more

4 mentions without citation

Structure and topology of the huntingtin 1-17 membrane anchor by a combined solution and solid-state NMR approach.
Michalek et al. (2013)
3 more