› 2lfg

Solution NMR

Solution structure of the human prolactin receptor ecd domain d2

Released:
DOI: 10.2210/pdb2lfg/pdb
PDB entry 2lfg coloured by chain, ensemble of 20 models, front view.
PDB entry 2lfg coloured by chain, ensemble of 20 models, side view.
PDB entry 2lfg coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation: insight from structures of the prolactin receptor.
Dagil R, Knudsen MJ, Olsen JG, O'Shea C, Franzmann M, Goffin V, Teilum K, Breinholt J, Kragelund BB
Structure 20 270-82 (2012)
PMID: 22325776

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147736 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prolactin receptor Chain: A
Molecule details ›
Chain: A
Length: 113 amino acids
Theoretical weight: 13.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P16471 (Residues: 123-234; Coverage: 19%)
Gene name: PRLR
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 91%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

12 review citations

Cytokines in radiobiological responses: a review.
Schaue et al. (2012)
11 more

5 mentions without citation

Inherited biallelic CSF3R mutations in severe congenital neutropenia.
Triot et al. (2014)
4 more