› 2lha

Solution NMR

Solution structure of C2B with IP6

Released:
DOI: 10.2210/pdb2lha/pdb
PDB entry 2lha coloured by chain, ensemble of 10 models, front view.
PDB entry 2lha coloured by chain, ensemble of 10 models, side view.
PDB entry 2lha coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Molecular level interaction of inositol hexaphosphate with the C2B domain of human synaptotagmin I.
Joung MJ, Mohan SK, Yu C
Biochemistry 51 3675-83 (2012)
PMID: 22475172

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149302 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Synaptotagmin-1 Chain: A
Molecule details ›
Chain: A
Length: 152 amino acids
Theoretical weight: 17.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21579 (Residues: 271-422; Coverage: 36%)
Gene names: SVP65, SYT, SYT1
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

1 bound ligand:
Ligand IHP 1 x IHP
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 85%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Signaling through C2 domains: more than one lipid target.
Corbalan-Garcia et al. (2014)
10 other articles

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)