› 2lje

Solution NMR

Biphosphorylated (747pY, 759pY) beta3 integrin cytoplasmic tail under membrane mimetic conditions

Released:
DOI: 10.2210/pdb2lje/pdb
PDB entry 2lje coloured by chain, ensemble of 15 models, front view.
PDB entry 2lje coloured by chain, ensemble of 15 models, side view.
PDB entry 2lje coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Tyrosine phosphorylation as a conformational switch: a case study of integrin β3 cytoplasmic tail.
Deshmukh L, Meller N, Alder N, Byzova T, Vinogradova O
J Biol Chem 286 40943-53 (2011)
PMID: 21956114

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138433 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin beta-3 Chain: A
Molecule details ›
Chain: A
Length: 67 amino acids
Theoretical weight: 7.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05106 (Residues: 742-788; Coverage: 6%)
Gene names: GP3A, ITGB3
Sequence domains: Integrin beta cytoplasmic domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PTR 2 x PTR

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 82%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Distinct functions for Rap1 signaling in vascular morphogenesis and dysfunction.
Chrzanowska-Wodnicka M. (2013)
3 more

3 mentions without citation

Tyrosine phosphorylation as a conformational switch: a case study of integrin β3 cytoplasmic tail.
Deshmukh et al. (2011)
2 more