› 2lk4

Solution NMR

Structural and mechanistic insights into the interaction between PAT Pyk2 and Paxillin LD motif

Released:
DOI: 10.2210/pdb2lk4/pdb
PDB entry 2lk4 coloured by chain, ensemble of 20 models, front view.
PDB entry 2lk4 coloured by chain, ensemble of 20 models, side view.
PDB entry 2lk4 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural and mechanistic insights into the interaction between Pyk2 and paxillin LD motifs.
Vanarotti MS, Miller DJ, Guibao CD, Nourse A, Zheng JJ
J Mol Biol 426 3985-4001 (2014)
PMID: 25174335

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171983 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein-tyrosine kinase 2-beta Chain: A
Molecule details ›
Chain: A
Length: 135 amino acids
Theoretical weight: 14.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14289 (Residues: 871-1005; Coverage: 13%)
Gene names: FAK2, PTK2B, PYK2, RAFTK
Sequence domains: Focal adhesion targeting region
Structure domains: Nucleotidyltransferases domain 2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 84%
Refinement method: distance geometry
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The Non-receptor Tyrosine Kinase Pyk2 in Brain Function and Neurological and Psychiatric Diseases.
de Pins et al. (2021)
5 other articles