› 2lly

Solution NMR

NMR structures of the transmembrane domains of the nAChR a4 subunit

Released:
DOI: 10.2210/pdb2lly/pdb
PDB entry 2lly coloured by chain, ensemble of 20 models, front view.
PDB entry 2lly coloured by chain, ensemble of 20 models, side view.
PDB entry 2lly coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR structures of the transmembrane domains of the α4β2 nAChR.
Bondarenko V, Mowrey D, Tillman T, Cui T, Liu LT, Xu Y, Tang P
Biochim Biophys Acta 1818 1261-8 (2012)
PMID: 22361591

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155120 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuronal acetylcholine receptor subunit alpha-4 Chain: A
Molecule details ›
Chain: A
Length: 137 amino acids
Theoretical weight: 15.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43681 (Residues: 240-339, 598-626; Coverage: 22%)
Gene names: CHRNA4, NACRA4
Sequence domains: Neurotransmitter-gated ion-channel transmembrane region
Structure domains: Neurotransmitter-gated ion-channel transmembrane domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 84%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Gating of pentameric ligand-gated ion channels: structural insights and ambiguities.
daCosta et al. (2013)
3 more

10 mentions without citation

Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel.
Sauguet et al. (2013)
9 more