› 2lmb

Solution NMR

Solution Structure of C-terminal RAGE (ctRAGE)

Released:
DOI: 10.2210/pdb2lmb/pdb
PDB entry 2lmb coloured by chain, ensemble of 20 models, front view.
PDB entry 2lmb coloured by chain, ensemble of 20 models, side view.
PDB entry 2lmb coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Signal transduction in receptor for advanced glycation end products (RAGE): solution structure of C-terminal rage (ctRAGE) and its binding to mDia1.
Rai V, Maldonado AY, Burz DS, Reverdatto S, Yan SF, Schmidt AM, Shekhtman A
J Biol Chem 287 5133-44 (2012)
PMID: 22194616

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172192 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Advanced glycosylation end product-specific receptor Chain: A
Molecule details ›
Chain: A
Length: 43 amino acids
Theoretical weight: 5.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15109 (Residues: 362-404; Coverage: 11%)
Gene names: AGER, RAGE

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 59%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

29 review citations

Cellular signalling of the receptor for advanced glycation end products (RAGE).
Xie et al. (2013)
28 more

3 mentions without citation

Receptor for Advanced Glycation End Products (RAGE) and Mechanisms and Therapeutic Opportunities in Diabetes and Cardiovascular Disease: Insights From Human Subjects and Animal Models.
Egaña-Gorroño et al. (2020)
2 more