› 2lnl

Solid-state NMR

Structure of human CXCR1 in phospholipid bilayers

Released:
DOI: 10.2210/pdb2lnl/pdb
PDB entry 2lnl coloured by chain, ensemble of 10 models, front view.
PDB entry 2lnl coloured by chain, ensemble of 10 models, side view.
PDB entry 2lnl coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the chemokine receptor CXCR1 in phospholipid bilayers.
Park SH, Das BB, Casagrande F, Tian Y, Nothnagel HJ, Chu M, Kiefer H, Maier K, De Angelis AA, Marassi FM, Opella SJ
Nature 491 779-83 (2012)
PMID: 23086146

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150329 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-X-C chemokine receptor type 1 Chain: A
Molecule details ›
Chain: A
Length: 309 amino acids
Theoretical weight: 35.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P25024 (Residues: 20-328; Coverage: 88%)
Gene names: CMKAR1, CXCR1, IL8RA
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Structure domains: Rhodopsin 7-helix transmembrane proteins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 28%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

61 review citations

Molecular signatures of G-protein-coupled receptors.
Venkatakrishnan et al. (2013)
60 more

56 mentions without citation

The CXCL8-CXCR1/2 pathways in cancer.
Liu et al. (2016)
55 more