› 2lnx

Solution NMR

Solution structure of Vav2 SH2 domain

Released:
DOI: 10.2210/pdb2lnx/pdb
PDB entry 2lnx coloured by chain, ensemble of 20 models, front view.
PDB entry 2lnx coloured by chain, ensemble of 20 models, side view.
PDB entry 2lnx coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Identification and structural basis for a novel interaction between Vav2 and Arap3.
Wu B, Wang F, Zhang J, Zhang Z, Qin L, Peng J, Li F, Liu J, Lu G, Gong Q, Yao X, Wu J, Shi Y
J Struct Biol 180 84-95 (2012)
PMID: 22750419

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156616 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Guanine nucleotide exchange factor VAV2 Chain: A
Molecule details ›
Chain: A
Length: 122 amino acids
Theoretical weight: 14.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P52735 (Residues: 659-771; Coverage: 13%)
Gene name: VAV2
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 86%
Refinement method: simulated annealing
Expression system: Escherichia coli

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Citations

4 citation in other articles

ARAP3 functions in hematopoietic stem cells.
Song et al. (2014)
3 more