› 2lqn

Solution NMR

Solution structure of CRKL

Released:
DOI: 10.2210/pdb2lqn/pdb
PDB entry 2lqn coloured by chain, ensemble of 20 models, front view.
PDB entry 2lqn coloured by chain, ensemble of 20 models, side view.
PDB entry 2lqn coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII.
Jankowski W, Saleh T, Pai MT, Sriram G, Birge RB, Kalodimos CG
Nat Chem Biol 8 590-6 (2012)
PMID: 22581121

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155436 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Crk-like protein Chain: A
Molecule details ›
Chain: A
Length: 303 amino acids
Theoretical weight: 33.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P46109 (Residues: 1-303; Coverage: 100%)
Gene name: CRKL
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 58%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Protein dynamics and function from solution state NMR spectroscopy.
Kovermann et al. (2016)
5 more

2 mentions without citation

The Disordered Cellular Multi-Tasker WIP and Its Protein-Protein Interactions: A Structural View.
Sokolik et al. (2020)
1 more