› 2lqp

Solution NMR

NMR solution structure of the Ca2+-Calmodulin C-terminal domain in a complex with a peptide (NSCaTE) from the L-type Voltage-Gated Calcium Channel alpha1C subunit

Released:
DOI: 10.2210/pdb2lqp/pdb
PDB entry 2lqp coloured by chain, ensemble of 19 models, front view.
PDB entry 2lqp coloured by chain, ensemble of 19 models, side view.
PDB entry 2lqp coloured by chain, ensemble of 19 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the regulation of L-type voltage-gated calcium channels: interactions between the N-terminal cytoplasmic domain and Ca(2+)-calmodulin.
Liu Z, Vogel HJ
Front Mol Neurosci 5 38 (2012)
PMID: 22518098

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162916 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calmodulin Chain: A
Molecule details ›
Chain: A
Length: 71 amino acids
Theoretical weight: 8.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 62%
Refinement method: torsion angle dynamics, simulated annealing
Expression system: Escherichia coli

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Citations

12 review citations

Neuronal voltage-gated calcium channels: structure, function, and dysfunction.
Simms et al. (2014)
11 more

2 mentions without citation

Structural basis for the regulation of L-type voltage-gated calcium channels: interactions between the N-terminal cytoplasmic domain and Ca(2+)-calmodulin.
Liu et al. (2012)
1 more