› 2lr1

Solution NMR

Structural Mechanism for Bax Inhibition by Cytomegalovirus Protein vMIA

Released:
DOI: 10.2210/pdb2lr1/pdb
PDB entry 2lr1 coloured by chain, ensemble of 20 models, front view.
PDB entry 2lr1 coloured by chain, ensemble of 20 models, side view.
PDB entry 2lr1 coloured by chain, ensemble of 20 models, top view.
Source organisms:
Primary publication:
Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA.
Ma J, Edlich F, Bermejo GA, Norris KL, Youle RJ, Tjandra N
Proc Natl Acad Sci U S A 109 20901-6 (2012)
PMID: 23213219

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147813 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Apoptosis regulator BAX Chain: A
Molecule details ›
Chain: A
Length: 192 amino acids
Theoretical weight: 21.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07812 (Residues: 1-192; Coverage: 100%)
Gene names: BAX, BCL2L4
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like
UL37 immediate early glycoprotein Chain: B
Molecule details ›
Chain: B
Length: 21 amino acids
Theoretical weight: 2.73 KDa
Source organism: Human herpesvirus 5 strain AD169
Expression system: Not provided
UniProt:
  • Canonical: P16778 (Residues: 130-150; Coverage: 5%)
Gene name: UL37

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DGSA-distance geometry simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

11 review citations

Many players in BCL-2 family affairs.
Moldoveanu et al. (2014)
10 more

10 mentions without citation

Too much death can kill you: inhibiting intrinsic apoptosis to treat disease.
Li et al. (2021)
9 more