› 2lsi

Solution NMR

Solution structure of polymerase-interacting domain of human Rev1 in complex with translesional synthesis polymerase kappa

Released:
DOI: 10.2210/pdb2lsi/pdb
PDB entry 2lsi coloured by chain, ensemble of 15 models, front view.
PDB entry 2lsi coloured by chain, ensemble of 15 models, side view.
PDB entry 2lsi coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Entry authors: Liu D, Ryu K, Ko J, Choi B

Function and Biology Details

Reaction catalysed: 
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193675 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DNA repair protein REV1 Chain: A
Molecule details ›
Chain: A
Length: 99 amino acids
Theoretical weight: 11.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UBZ9 (Residues: 1156-1251; Coverage: 8%)
Gene names: REV1, REV1L
Sequence domains: DNA repair protein REV1 C-terminal domain
Structure domains: DNA repair protein Rev1, C-terminal domain
DNA polymerase kappa Chain: B
Molecule details ›
Chain: B
Length: 17 amino acids
Theoretical weight: 2.16 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9UBT6 (Residues: 562-577; Coverage: 2%)
Gene names: DINB1, POLK

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 91%
Refinement method: simulated annealing, explicit water refinement
Expression systems:
  • Escherichia coli
  • Not provided

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