› 2ltu

Solution NMR

Solution Structure of autoinhibitory domain of human AMP-activated protein kinase catalytic subunit

Released:
DOI: 10.2210/pdb2ltu/pdb
PDB entry 2ltu coloured by chain, ensemble of 20 models, front view.
PDB entry 2ltu coloured by chain, ensemble of 20 models, side view.
PDB entry 2ltu coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Xia B, Hu J

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157068 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
5'-AMP-activated protein kinase catalytic subunit alpha-2 Chain: A
Molecule details ›
Chain: A
Length: 62 amino acids
Theoretical weight: 7.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P54646 (Residues: 282-339; Coverage: 11%)
Gene names: AMPK, AMPK2, PRKAA2
Sequence domains: AMP-activated protein kinase, alpha subunit, autoinhibitory domain
Structure domains: DNA helicase RuvA subunit, C-terminal domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 85%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

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