› 2lwl

Solution NMR

Structural Basis for the Interaction of Human β-Defensin 6 and Its Putative Chemokine Receptor CCR2 and Breast Cancer Microvesicles

Released:
DOI: 10.2210/pdb2lwl/pdb
PDB entry 2lwl coloured by chain, ensemble of 20 models, front view.
PDB entry 2lwl coloured by chain, ensemble of 20 models, side view.
PDB entry 2lwl coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis for the Interaction of Human ��-Defensin 6 and Its Putative Chemokine Receptor CCR2 and Breast Cancer Microvesicles.
De Paula VS, Gomes NS, Lima LG, Miyamoto CA, Monteiro RQ, Almeida FC, Valente AP
J. Mol. Biol. (2013)
PMID: 23938203

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185348 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-defensin 106 Chain: A
Molecule details ›
Chain: A
Length: 49 amino acids
Theoretical weight: 5.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N104 (Residues: 21-65; Coverage: 100%)
Gene names: BD6, DEFB106, DEFB106A, DEFB106B, DEFB6
Sequence domains: Beta defensin
Structure domains: Antimicrobial Peptide, Beta-defensin 2; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 88%
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Defensins: antifungal lessons from eukaryotes.
Silva et al. (2014)
2 more

5 mentions without citation

A Dynamic Overview of Antimicrobial Peptides and Their Complexes.
de Paula et al. (2018)
4 more